Mirin: identifying microRNA regulatory modules in protein-protein interaction networks

UNLABELLED Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer. AVAILABILITY AND IMPLEMENTATION Mirin is freely available at http://mirin.ym.edu.tw/. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.